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These DSBs are usually repaired by homologous directed repair (HDR) or nonhomologous end joining (NHEJ), achieving mutation or foreign gene insertion (Fig

Emerging microbiome-based therapies, including targeted microbial consortia, engineered probiotics, and metabolite-directed interventions, offer additional options for modulating activity of microbiotagutbrain axis, with ongoing research focusing on personalized treatment strategies and the development of biomarkers for better therapeutic targeting [254,268]